Abstract #0363
Three-dimensional mapping of brain venous oxygenation using T2-oximetry
Deng Mao 1 and Hanzhang Lu 1
1
Advanced Imaging Research Center, Univ of
Texas Southwestern Medical Center, Dallas, TX, United
States
Quantification of venous oxygenation is a critical
component for understanding brain metabolism. The
present study aimed to develop a non-invasive, efficient
and reproducible technique to map brain venous
oxygenation in 3D. Our method has utilized phase
contrast principle to isolate pure blood signal and
measure its T2* from its signal decay in multi-echo
gradient echo by mono-exponetial fitting. The fitted
blood T2* can be converted into oxygenation level though
in vitro calibration curve.This novel T2-base oximetry
implementation has successfully provided a 3D map of
blood T2* and oxygenation and demonstrated excellent
reproducible.
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