Three-dimensional mapping of brain venous oxygenation using T2-oximetry

Quantification of venous oxygenation is a critical component for understanding brain metabolism. The present study aimed to develop a non-invasive, efficient and reproducible technique to map brain venous oxygenation in 3D. Our method has utilized phase contrast principle to isolate pure blood signal and measure its T2* from its signal decay in multi-echo gradient echo by mono-exponetial fitting. The fitted blood T2* can be converted into oxygenation level though in vitro calibration curve.This novel T2-base oximetry implementation has successfully provided a 3D map of blood T2* and oxygenation and demonstrated excellent reproducible.

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