Meeting Banner
Abstract #0364

Classification of in vivo drug function through a coupling model and PET/fMRI

Christin Y. Sander 1 , Jacob M. Hooker 1 , Ciprian Catana 1 , Bruce R. Rosen 1,2 , and Joseph B. Mandeville 1

1 A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2 Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States

The pharmacological response of a drug is currently defined through in vitro studies and characterized by parameters such as in vitro efficacy and affinity. We propose an in vivo classification of drug function by PET/fMRI and demonstrate a coupling model that can predict the functional response measured by fMRI. Experimental results at the D2/D3 dopamine system show that we can classify agonists and antagonists according to their fMRI response, suggesting that we can characterize drug function and efficacy to inform about the in vivo potency of a drug.

This abstract and the presentation materials are available to members only; a login is required.

Join Here