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Abstract #0366

Comparison of MRI Contrast Enhancement with Molecular Distribution Following FUS-Mediated BBB Opening

Michael Valdez 1 , Shelby Yuan 1 , Zhonglin Liu 1 , Paul Helquist 2 , Terry Matsunaga 1 , Russell Witte 1 , Lars Furenlid 1 , Marek Romanowski 1 , and Ted Trouard 1

1 University of Arizona, Tucson, Arizona, United States, 2 University of Notre Dame, Indiana, United States

Treatment of neurological disorders is often hampered by the inability of therapeutics to cross the blood-brain barrier (BBB). Techniques that use focused ultrasound (FUS) and microbubbles have been developed that temporarily open the BBB. While the opening of the BBB is readily seen on contrast-enhanced MRI, this only shows the distribution of contrast agent and not necessarily the opening to therapeutics. In this work, we have employed MRI, SPECT, CT, autoradiography, and fluorescence microscopy in mice to compare the distribution of contrast agents and model therapeutics within the brain following FUS-mediated BBB opening.

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