Abstract #0367
In vivo monitoring of ultrasound-mediated nanoparticle delivery in human colon cancer xenografts using magnetization-prepared rapid gradient echo (MPRAGE) imaging
Steven B Machtaler 1 , Bragi Svensson 1 , Tzu-Yin Wang 1 , Jung Woo Choe 2 , Kanyi Pu 1 , James Rioux 1 , Brian Rutt 1 , Pierre Khuri-Yakub 2 , Brian A. Hargreaves 1 , and Juergen K. Willmann 1
1
Radiology, Stanford, Stanford, CA, United
States,
2
Stanford,
CA, United States
Ultrasound-mediated vascular permeabilization is
currently being explored as a mechanism for
site-specific delivery of therapeutics; however, a
method to quantify therapeutic delivery in vivo is
required for clinical translation. We investigated the
feasibility of assessing ultrasound-mediated
nanoparticle delivery into colon cancer xenografts by
quantifying gadolinium-conjugated fluorescent
nanoparticle accumulation using MPRAGE imaging. We
observed a detectable drop in T1 in tumours after
US-mediated treatment that corresponded to an increase
in the nanoparticle accumulation observed ex vivo. This
approach has the potential to non-invasively quantify
drug delivery efficiency within a targeted tissue and
spatially map regions where successful delivery has
occurred.
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