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Abstract #0367

In vivo monitoring of ultrasound-mediated nanoparticle delivery in human colon cancer xenografts using magnetization-prepared rapid gradient echo (MPRAGE) imaging

Steven B Machtaler 1 , Bragi Svensson 1 , Tzu-Yin Wang 1 , Jung Woo Choe 2 , Kanyi Pu 1 , James Rioux 1 , Brian Rutt 1 , Pierre Khuri-Yakub 2 , Brian A. Hargreaves 1 , and Juergen K. Willmann 1

1 Radiology, Stanford, Stanford, CA, United States, 2 Stanford, CA, United States

Ultrasound-mediated vascular permeabilization is currently being explored as a mechanism for site-specific delivery of therapeutics; however, a method to quantify therapeutic delivery in vivo is required for clinical translation. We investigated the feasibility of assessing ultrasound-mediated nanoparticle delivery into colon cancer xenografts by quantifying gadolinium-conjugated fluorescent nanoparticle accumulation using MPRAGE imaging. We observed a detectable drop in T1 in tumours after US-mediated treatment that corresponded to an increase in the nanoparticle accumulation observed ex vivo. This approach has the potential to non-invasively quantify drug delivery efficiency within a targeted tissue and spatially map regions where successful delivery has occurred.

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