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Abstract #0368

Combined 19F MRI and CT imaging for the visualization of delayed release of compounds using pH-sensitive polymers coated capsules in vitro and in a hamster animal model

Sayuan Liang 1 , Dominiek Staelens 2 , Bernard Appeltans 3 , Marlies Van de Wouwer 3,4 , Guy Van den Mooter 3 , Gert Van Assche 2 , Greetje Vande Velde 1 , and Uwe Himmelreich 1

1 Department of Imaging & Pathology, KU Leuven, Leuven, Flemish Brabant, Belgium, 2 Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Flemish Brabant, Belgium, 3 Department of pharmaceutical and pharmacological sciences, KU Leuven, Leuven, Flemish Brabant, Belgium, 4 PharmAbs, KU Leuven, Leuven, Flemish Brabant, Belgium

In vivo imaging of controlled release in the gastrointestinal tract is of major importance to assess its efficacy. In this study, we establish a dual modal imaging platform by combining 19F MRI and CT using 19FDG and BaSO4 as contrast agent respectively which can provides information on the location, integrity and release of material from the capsule into the gastrointestinal tract of small animal models for the first time.

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