Abstract #0371
Multimodal in vivo evaluation of a surface-switching nanoparticle platform
Francois Fay 1 , Line Hansen 2 , Stephanie J. Hectors 3 , Jun Tang 1 , Anita Gianella 1 , Brenda L. Sanchez-Gaytan 1 , Yiming Zhao 1 , Aneta J. Mieszawska 1 , Robert Langer 4 , Claudia Calcagno 1 , Gustav J. Strijkers 3,5 , Zahi A. Fayad 1 , and Willem J.M. Mulder 1,5
1
Translational and Molecular Imaging
Institute, Icahn School of Medicine at Mount Sinai, New
York City, New York, United States,
2
Interdisciplinary
Nanoscience Center, Aarhus University, Aarhus, Denmark,
3
Biomedical
NMR, Department of Biomedical Engineering, Eindhoven
University of Technology, Eindhoven, Netherlands,
4
Department
of Chemical Engineering, Massachusetts Institute of
Technology, Cambridge, Massachusetts, United States,
5
Department
of Vascular Medicine, Academic Medical Center,
Amsterdam, Netherlands
We have developed a hybrid lipid-polymer nanoparticle
platform, which has a matrix metalloproteinase-2 (MMP2)
cleavable polyethylene glycol (PEG)-lipid corona. Near
infrared fluorescent dyes and paramagnetic lipids were
incorporated to enable dual in vivo optical and magnetic
resonance imaging. In the current study we demonstrated
that upon incubation with MMP2 the PEG shielding is
removed enabling the targeting ligands (RGD peptides) to
bind to αvβ3 integrin expressing cells. In vivo mouse
imaging revealed that following an intravenous
administration our nanoparticles accumulated in the rim
of orthotopically implanted breast tumors.
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