Abstract #0372
On-off switchable nanoparticles for improved detection with MRI
Bradley D Hann 1 and Kevin M Bennett 1
1
Biology, University of Hawaii at Manoa,
Honolulu, HI, United States
If contrast agent relaxivity could be temporally
modulated from an external source, it may lower the
minimum detectable concentration of in inhomogeneous
tissue. We have developed a thermally on-off switchable
nanoparticle that decreases in r1 when raised above the
switching temperature threshold. Next we simulated the
tissue regions where a switchable particle would be
detectable in lower concentrations than a non-switchable
one. This may be useful for molecular imaging in
inhomogeneous tissue such as the liver, kidney, or
spleen.
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