On-off switchable nanoparticles for improved detection with MRI

If contrast agent relaxivity could be temporally modulated from an external source, it may lower the minimum detectable concentration of in inhomogeneous tissue. We have developed a thermally on-off switchable nanoparticle that decreases in r1 when raised above the switching temperature threshold. Next we simulated the tissue regions where a switchable particle would be detectable in lower concentrations than a non-switchable one. This may be useful for molecular imaging in inhomogeneous tissue such as the liver, kidney, or spleen.

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