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Abstract #0373

PSMA-Specific Theranostic Nanoplexes for Combination Gene and Prodrug Therapy of Prostate Cancer

Zhihang Chen 1 , Marie-France Penet 1 , Balaji Krishnamachary 1 , Sangeeta Ray Banerjeee 1 , Martin G. Pomper 1 , and Zaver M. Bhujwalla 1

1 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Prostate cancer (PCa) is the second leading cause of death from cancer in men in the U.S., and there is a compelling need for the development of effective treatments for metastatic PCa. Prostate-specific membrane antigen (PSMA) is a membrane protein that has abundant and restricted expression on the surface of castrate-resistant PCa, and is therefore a promising target for combined diagnosis and therapy of metastatic PCa. Here we achieved PSMA-specific delivery of a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cDNA gene and a prodrug enzyme bacterial cytosine deaminase (bCD) using a nanoplex based polyethyleneimine (PEI) platform.

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