Simultaneous quantification of liver perfusion and hepatocyte uptake function with dynamic gadoxetate-enhanced MR imaging in patients with chronic liver diseases
Benjamin Leporq 1 , Sabine Schmidt 2 , Catherine Pastor 1,3 , Jean Luc Daire 1 , and Bernard Edgar Van Beers 1,4
Center of research on inflammation, Paris 7
University; INSERM U1044, Paris, France,
of Radiology, Centre Hospitalier Universitaire Vaudois,
de Physiopathologie Hpatique et Imagerie Molculaire,
Hpitaux Universitaires de Genve, Geneva, Switzerland,
of Radiology, Beaujon University hospital Paris Nord,
This study aims to evaluate the feasibility of
quantifying simultaneously the liver perfusion and
hepatocyte uptake function with dynamic gadoxetate-enhanced
MR imaging in patients with chronic liver diseases.
Dynamic imaging was performed and gadoxetate kinetics
was modeled with a dual input dual compartment uptake
model. Both increase of hepatic artery fraction of liver
perfusion and decrease of hepatocyte gadoxetate uptake
in patients with chronic liver diseases were observed.
These results suggest that pharmacokinetic parameters at
dynamic gadoxetate-enhanced MR imaging have the
potential to become imaging biomarkers of both liver
perfusion and hepatocyte function in patients with
chronic liver diseases.
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