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Abstract #0388

Assessment of liver fibrosis in rats by MRI with apparent diffusion coefficient and T1 relaxation time in the rotating frame

Genwen Hu 1,2 , Xianyue Quan 1 , Xiaoying Lin 2 , Queenie Chan 3 , Yingjie Mei 4 , Xuhui Zhang 1 , and Yufa Li 5

1 Medical Image Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China, 2 Medical Image Center,Shenzhen Bao'an Maternal and Child Health Hospital, Shenzhen, Guangdong, China, 3 Philips Healthcare, Hong Kong, China, 4 Philips Healthcare, Guangzhou, Guandong, China, 5 Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China

The purpose of this study was to explore the characteristics of ADC and T1 in various stages of liver fibrosis in CCl4-induced rats. ADC and T1 MRI were performed with a 3.0T clinical scanner. Stages of liver fibrosis were evaluated using METAVIR scores (stage F0-stage F4) of liver serial sections stained with hematoxylin and eosin and Massons trichrome. Nonparametric methods and receiver operating characteristic (ROC) curve analyses were used to determine diagnostic accuracy. ADC and T1 showed significant correlations with stages of liver fibrosis in a rat model, where T1 is regarded to be superior to ADC in distinguishing the stages.

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