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Abstract #0389

Advanced Assessment of Liver Diseases with Magnetic Resonance Elastography in Animal Models

Meng Yin 1 , Ruisi Wang 2 , Usman Yaqoob 2 , Shennen A. Mao 3 , Jaime M. Glorioso 3 , Kevin J. Glaser 1 , Liu Yang 2 , Vijay Shah 2 , Scott L. Nyberg 3 , and Richard L. Ehman 1

1 Radiology, Mayo Clinic, Rochester, Minnesota, United States, 2 Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States, 3 Transplatation Surgery, Mayo Clinic, Rochester, Minnesota, United States

To investigate the utility of MRE-derived mechanical properties in characterizing diseased hepatic tissue, we performed multifrequency 3-D/3-axis MRE on two mouse models with carbon tetrachloride (CCl4) induced chronic liver injury and one Fumarylacetoacetate hydrolase (FAH) deficient pig model with chronic liver disease. Liver stiffness, phase angle, storage and loss modulus frequency dispersions were selected for evaluation. Results demonstrated distinct and potentially characteristic changes in these mechanical properties with hepatic inflammation, fibrosis and increased portal pressure. The findings offer preliminary evidence of the potential to extend MRE to distinguish and independently assess necroinflammatory and fibrotic processes.

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