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Abstract #0396

Corpus Callosum Atrophy Rate in Mild Cognitive Impairment and Prodromal Alzheimers Disease

Babak Ardekani 1,2 , Sahar Elahi 1 , Alvin Bachman 1 , Sang Han Lee 1 , and John Sidtis 1,2

1 The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, United States, 2 Department of Psychiatry, New York University School of Medicine, New York, NY, United States

We examined temporal rates of change in CC morphology in MCI patients to determine the differences between converters to AD and non-converters. The spatial and temporal patterns of CC morphological change in MCI-NC are similar to healthy controls, while those in MCI-C are similar to very mild/mild AD. CC atrophy is quantifiable in a one-year longitudinal observation period, making this a practical imaging biomarker. Amongst the measures considered, circularity proved to be the most sensitive measure separating convertors from non-convertors regardless of their gender.

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