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Abstract #0397

Increased cortical volume revealed by atlas-based volumetry in a bigenic mouse model of Alzheimer's Disease

Kristof Govaerts 1 , Janaki Raman Rangarajan 2 , Tom Struys 3 , Fred Van Leuven 4 , Uwe Himmelreich 1 , and Tom Dresselaers 1

1 Imaging & Pathology, KU Leuven, Leuven, Vlaams-Brabant, Belgium, 2 Electrical Engineering, KU Leuven, Leuven, Vlaams-Brabant, Belgium, 3 Morphology, Universiteit Hasselt, Hasselt, Limburg, Belgium, 4 Human Genetics, KU Leuven, Leuven, Vlaams-Brabant, Belgium

Although atrophy is a well-established biomarker for Alzheimers Disease (AD) in human patients, MRI-based studies on this subject in mice are scarce. Here, we made use of an atlas-based registration protocol, and we show that the bigenic biAT mouse model displays increased rather than decreased cortical volume, both at 3 and at 12 months of age. Differences were small but highly significant. Histological assessment also showed decreased neuronal density in the frontal cortex.

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