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Abstract #0398

Cortical volume and perfusion are influenced by vascular risk factors in addition to cognitive status: new insight made available from the ADNI study

Ekaterina Tchistiakova 1,2 and Bradley J. MacIntosh 1,2

1 Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2 Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada

Recent studies demonstrated that vascular risk factors (VRFs) increase the risk of AD. Little, however, is known on the interaction of AD progression and VRF burden and their impact on brain health. In this study we used a multivariate approach to examine the impact of VRFs on the cortical volume in normal controls and MCI groups. Our results indicate that cortical volume variability is predominantly driven by MCI individuals with high VRF burden. Our secondary analysis showed no association between cortical volumes and cerebral blood flow in those groups, but it was apparent in MCI individuals with low VRF burden.

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