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Abstract #0399

Brain Magnetic Susceptibility is Increased with Cognitive Impairment in a Community Population

Armin Eilaghi 1,2 , D Adam McLean 3 , Cheryl R. McCreary 1,2 , David Gobbi 3 , M Louis Lauzon 1,2 , Marina Salluzzi 3 , Eric E Smith 1,2 , and Richard Frayne 1,2

1 Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada, 2 Seaman Family MR Centre, Foothills Medical Centre, Calgary, Alberta, Canada, 3 Calgary Image Processing and Analysis Centre, Foothills Medical Centre, Calgary, Alberta, Canada

We demonstrated that susceptibility obtained with QSM was significantly higher in the cognitively impaired group than the normal group, after controlling for age in a cohort of volunteers drawn from the community. This proof-of-concept study underscores the potential value of susceptibility to distinguish cognition decline at the early, pre-symptomatic phase.

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