Abstract #0400

Regional cerebral iron concentrations as indicated by magnetic susceptibilities measured with Quantitative Susceptibility Mapping (QSM) at 7 Tesla correlate with brain Aβ plaque density as measured by 11-C-Pittsburgh Compound B Positron-Emission-Tomography (PiB-PET) in elderly subjects at risk for Alzheimers disease (AD)

Jiri M.G. van Bergen ^1,2 , Xu Li ² , Michael Wyss ³ , Simon J. Schreiner ¹ , Stefanie C. Steininger ¹ , Anton F. Gietl ¹ , Valerie Treyer ^1,4 , Sandra E. Leh ¹ , Fred Buck ⁴ , Jun Hua ² , Roger Nitsch ¹ , Klaas P. Pruessmann ³ , Peter C.M. van Zijl ² , Christoph Hock ¹ , and Paul G. Unschuld ¹

¹ Division of Psychiatry Research and Psychogeriatric Medicine, University of Zurich, Zurich, Zurich, Switzerland, ² F.M. Kirby center for Functional Brain Imaging, Kennedy Krieger Institute and Johns Hopkins School of Medicine, Baltimore, Maryland, United States, ³ Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland, ⁴ Division of Nuclear Medicine, University of Zurich, Zurich, Switzerland

In subjects with Mild Cognitive Impairment it was shown that susceptibility values as measured by Quantitative Susceptibility Mapping (QSM) correlate with A lower case Greek beta

plaque density as measured by 11-C-Pittsburgh Compound B Positron-Emission-Tomography (PiB-PET). Susceptibility in gray matter has been shown to relate to tissue iron content. Correlations were observed in the frontal, parietal, temporal and occipital cortices and the caudate nucleus. The correlation was driven by carriers of the Apolipoprotein E gene, an Alzheimers Disease (AD) associated risk factor. Our results suggest that cerebral iron accumulation may reflect A lower case Greek beta

associated brain dysfunction in subjects at increased risk for late onset AD.

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