Abstract #0414
Citicoline as a theranostic agent detected by CEST MRI
Hanwei Chen 1,2 , Yuguo Li 1,3 , Anna Jablonska 1 , Shuixing Zhang 4 , Jeff W Bulte 1,3 , Peter C.M. Van Zijl 1,3 , Mirek Janowski 1,5 , Piotr Walczak 1 , and Guanshu Liu 1,3
1
Department of Radiology, Johns Hopkins
University, Baltimore, MD, United States,
2
Radiology,
Guangzhou Panyu Central Hospital, Guangzhou, Guangdong,
China,
3
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, MD, United States,
4
Department
of Radiology, Guangdong General Hospital, Guangzhou,
Guangdong, China,
5
NeuroRepair
Department, MMRC PAS, Warsaw, Poland
Cytidine-5-diphosphocholine (citicoline or CDP-choline)
is a highly safe supplement with well-documented
neuroprotective effects, and has been approved for the
treatment of head trauma, stroke, and neurodegenerative
disease. In the present study, we aimed to explore the
possibility to use citicholine as an imaging agent
detected by CEST MRI. Our results demonstrated that
citicholine has a desirable CEST MRI contrast at 2 ppm,
which enables the direct imaging of drug delivery of
citicholine-loaded liposomes in the brain after stroke,
indicating such a system can be used as not only a
therapeutics but also a diagnostics of brain damage.
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