Meeting Banner
Abstract #0414

Citicoline as a theranostic agent detected by CEST MRI

Hanwei Chen 1,2 , Yuguo Li 1,3 , Anna Jablonska 1 , Shuixing Zhang 4 , Jeff W Bulte 1,3 , Peter C.M. Van Zijl 1,3 , Mirek Janowski 1,5 , Piotr Walczak 1 , and Guanshu Liu 1,3

1 Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2 Radiology, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong, China, 3 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4 Department of Radiology, Guangdong General Hospital, Guangzhou, Guangdong, China, 5 NeuroRepair Department, MMRC PAS, Warsaw, Poland

Cytidine-5-diphosphocholine (citicoline or CDP-choline) is a highly safe supplement with well-documented neuroprotective effects, and has been approved for the treatment of head trauma, stroke, and neurodegenerative disease. In the present study, we aimed to explore the possibility to use citicholine as an imaging agent detected by CEST MRI. Our results demonstrated that citicholine has a desirable CEST MRI contrast at 2 ppm, which enables the direct imaging of drug delivery of citicholine-loaded liposomes in the brain after stroke, indicating such a system can be used as not only a therapeutics but also a diagnostics of brain damage.

This abstract and the presentation materials are available to members only; a login is required.

Join Here