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Abstract #0416

Radical-free mixture of co-polarized 13C-metabolites for probing separate biochemical pathways simultaneously in vivo by hyperpolarized 13C MR

Jessica AM Bastiaansen 1,2 , Hikari AI Yoshihara 3,4 , Andrea Capozzi 3 , Juerg Schwitter 4 , Matthew E Merritt 5 , and Arnaud Comment 3

1 Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2 Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 3 Institute of Physics of Biological Systems, EPFL, Lausanne, Switzerland, 4 Division of Cardiology and Cardiac MR Center, University Hospital Lausanne (CHUV), Lausanne, Switzerland, 5 Advanced Imaging Research Center,Department of Radiology,Molecular Biophysics,Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, Texas, United States

The combination of hyperpolarized 13C technology and co-administration of separate imaging agents enables simultaneous monitoring of separate metabolic pathways in vivo in a single experiment. However, for clinical applications, it is currently necessary to use 13C preparations containing persistent radicals which require a time consuming filtration process before the injection, resulting in polarization losses. Here we present a radical-free, additive-free method, to co-hyperpolarize mixtures of 13C-labeled metabolites and respective in vivo detection in the heart. This study illustrates a method for measuring substrate competition that could be generalized to humans.

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