Abstract #0418
Image-guided delivery of liposomal nano-constructs targeting tumor vasculature
Sudath Hapuarachchige 1 , Yoshinori Kato 1,2 , Wenlian Zhu 1 , Joseph M Backer 3 , Marina V Backer 3 , Susanta K Sarkar 4 , and Dmitri Artemov 1,5
1
Department of Radiology & Radiological
Science, Johns Hopkins University School of Medicine,
Baltimore, MD, United States,
2
Life
Science Tokyo Advanced Research Center, Hoshi
University, Japan,
3
SibTec,
Inc., Brookfield, CT, United States,
4
Sanofi
Oncology, Cambridge, MA, United States,
5
Department
of Oncology, Johns Hopkins University School of
Medicine, Baltimore, MD, United States
Noninvasive tracking of drug-loaded nanocarriers adds
significant value to cancer chemotherapy by allowing
prediction of thetherapy outcome, which will eventually
benefit cancer patients. Superparamagnetic iron oxide
nanoparticles (SPIONs) are highly sensitive MRI contrast
agents. However, rapid clearance of SPIONs by the
reticuloendothelial system, presents significant
problems for their use as an image-guided drug delivery
platform. This study was intended to investigate if
tumor delivery of SPIONs can be enhanced by
encapsulating them in liposomes for either passive
delivery via the enhanced permeability and retention
effect (EPR) or active delivery via the receptors for
vascular endothelial growth factor (VEGF).
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