Meeting Banner
Abstract #0418

Image-guided delivery of liposomal nano-constructs targeting tumor vasculature

Sudath Hapuarachchige 1 , Yoshinori Kato 1,2 , Wenlian Zhu 1 , Joseph M Backer 3 , Marina V Backer 3 , Susanta K Sarkar 4 , and Dmitri Artemov 1,5

1 Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 Life Science Tokyo Advanced Research Center, Hoshi University, Japan, 3 SibTec, Inc., Brookfield, CT, United States, 4 Sanofi Oncology, Cambridge, MA, United States, 5 Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Noninvasive tracking of drug-loaded nanocarriers adds significant value to cancer chemotherapy by allowing prediction of thetherapy outcome, which will eventually benefit cancer patients. Superparamagnetic iron oxide nanoparticles (SPIONs) are highly sensitive MRI contrast agents. However, rapid clearance of SPIONs by the reticuloendothelial system, presents significant problems for their use as an image-guided drug delivery platform. This study was intended to investigate if tumor delivery of SPIONs can be enhanced by encapsulating them in liposomes for either passive delivery via the enhanced permeability and retention effect (EPR) or active delivery via the receptors for vascular endothelial growth factor (VEGF).

This abstract and the presentation materials are available to members only; a login is required.

Join Here