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Abstract #0419

Micro-MRI and Fluorescence Imaging of Myeloperoxidase Activity in Human Brain Vascular Pathology

Dung Minh Hoang 1 , Matthew J Gounis 2 , Youssef Zaim Wadghiri 1 , Peter Caravan 3 , and Alexei A Bogdanov Jr. 2

1 Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging, New York University, New York, NY, United States, 2 Radiology, University of Massachusetts Medical School, Worcester, MA, United States, 3 Radiology, A.Martinos' Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

We aimed to investigate the feasibility of imaging myeloperoxidase (MPO) activity, i.e a marker of vessel wall inflammation and instability with novel paramagnetic (DOTAGA(Gd)-5-hydroxytryptamide) and fluorescent (Cy3-5-hydroxytryptamide) substrates in surgically excised specimens of human ruptured and unruptured intracranial aneurysms using fluorescence and micro-MR imaging. Fluorescent MPO substrate resulted in localized staining of several areas in the adventitia of the ruptured aneurysm as well as perivascular areas within the lumen of the unruptured samples. The highly detailed MR images (57-m in-plane resolution) acquired revealed the presence of high focal T1w-enhancement corresponding to the blood vessel wall and atherosclerotic plaque.

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