Abstract #0419
Micro-MRI and Fluorescence Imaging of Myeloperoxidase Activity in Human Brain Vascular Pathology
Dung Minh Hoang 1 , Matthew J Gounis 2 , Youssef Zaim Wadghiri 1 , Peter Caravan 3 , and Alexei A Bogdanov Jr. 2
1
Radiology, Bernard and Irene Schwartz Center
for Biomedical Imaging, New York University, New York,
NY, United States,
2
Radiology,
University of Massachusetts Medical School, Worcester,
MA, United States,
3
Radiology,
A.Martinos' Center for Biomedical Imaging, Massachusetts
General Hospital, Charlestown, MA, United States
We aimed to investigate the feasibility of imaging
myeloperoxidase (MPO) activity, i.e a marker of vessel
wall inflammation and instability with novel
paramagnetic (DOTAGA(Gd)-5-hydroxytryptamide) and
fluorescent (Cy3-5-hydroxytryptamide) substrates in
surgically excised specimens of human ruptured and
unruptured intracranial aneurysms using fluorescence and
micro-MR imaging. Fluorescent MPO substrate resulted in
localized staining of several areas in the adventitia of
the ruptured aneurysm as well as perivascular areas
within the lumen of the unruptured samples. The highly
detailed MR images (57-m in-plane resolution) acquired
revealed the presence of high focal T1w-enhancement
corresponding to the blood vessel wall and
atherosclerotic plaque.
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