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Abstract #0420

Molecular Imaging Studies of a Robust Gd-Sucrose Scaffold Applied to MR-Colonography

Gary V. Martinez 1 , Parastou Foroutan 2 , Valerie E. Moberg 1 , Suryakiran Navath 3 , Roha Afzal 1 , Robert J. Gillies 1 , Eugene A. Mash 3 , and David L. Morse 1

1 Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States, 2 Bruker Biospin, Billerica, Massachusetts, United States, 3 Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States

Colorectal cancer (CRC) has a high incidence as it is the third most common cancer in both males and females, and the second leading cause of death from cancer in the United States. Despite these statistics, it is known that early detection can mitigate the risk and improve outcome dramatically, if detected early. In this work, we present an approach that may potentially mitigate all of the drawbacks of currently existing methods by using a Gd sucrose scaffold that has a high relaxivity, is robust and resilient to the GI tract, and may be administered orally with minimal bowel preparation.

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