Abstract #0421
Two-dimensional shaped voxel MRS in the human brain at 3 T
Patrick Waxmann 1 , Ralf Mekle 1 , Florian Schubert 1 , Andre Kuehne 2 , Tomasz Dawid Lindel 1 , Frank Seifert 1 , Oliver Speck 3 , and Bernd Ittermann 1
1
Physikalisch-Technische Bundesanstalt (PTB),
Braunschweig und Berlin, Berlin, Germany,
2
Medical
University of Vienna, Vienna, Austria,
3
Otto-von-Guericke-University,
Magdeburg, Germany
Spatially selective excitation (SSE) with parallel
transmission was applied as a means to acquire signal
from anatomy adapted voxels for in vivo 1H MR
spectroscopy. A novel method to select spectroscopy
voxels with two-dimensional arbitrary shapes was
investigated. An on/off scheme with an adiabatic slice
selective inversion pulse preceding a 2D-SSE pulse
enabled rapid free induction decay acquisitions. High
spatial fidelity of the SSE profiles on and off
resonance was achieved. Metabolite concentrations in
human brain determined with SHAVE were reliably
quantified with LCModel (CRLB < 20 %) and did not
deviate systematically from results acquired with a
conventional SPECIAL sequence.
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