In Vivo Quantification of ATP Synthesis Rates in Rat Skeletal Muscle by 31 P Spectroscopic Magnetic Resonance Fingerprinting
Charlie Yi Wang 1 , Yuchi Liu 1 , Mark Alan Griswold 1,2 , and Xin Yu 1,2
Biomedical Engineering, Case Western Reserve
University, Cleveland, Ohio, United States,
Case Western Reserve University, Cleveland, Ohio, United
ATP synthesis through ATP synthase rate measurement by
saturation transfer (ST) methods requires long
experiment times. A novel
magnetization transfer spectroscopic magnetic resonance
fingerprinting (MT-MRF) pulse sequence was designed to
encode magnetization transfer of ATP metabolites. The
flexibility in sequence design was utilized to improve
encoding of magnetization transfer through ATP synthase.
MT-MRF method was shown in vivo rat hind-limb to agree
with conventional ST method for ATP synthesis rate
MT-MRF exhibited improved measurement precision over ST
for rate measurement of ATP synthesis through ATP
synthase, suggesting decreased required imaging time.
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