Abstract #0422
In Vivo Quantification of ATP Synthesis Rates in Rat Skeletal Muscle by 31 P Spectroscopic Magnetic Resonance Fingerprinting
Charlie Yi Wang 1 , Yuchi Liu 1 , Mark Alan Griswold 1,2 , and Xin Yu 1,2
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, Ohio, United States,
2
Radiology,
Case Western Reserve University, Cleveland, Ohio, United
States
ATP synthesis through ATP synthase rate measurement by
conventional
31
P
saturation transfer (ST) methods requires long
experiment times. A novel
31
P
magnetization transfer spectroscopic magnetic resonance
fingerprinting (MT-MRF) pulse sequence was designed to
encode magnetization transfer of ATP metabolites. The
flexibility in sequence design was utilized to improve
encoding of magnetization transfer through ATP synthase.
Measurement using
31
P
MT-MRF method was shown in vivo rat hind-limb to agree
with conventional ST method for ATP synthesis rate
measurement.
31
P
MT-MRF exhibited improved measurement precision over ST
for rate measurement of ATP synthesis through ATP
synthase, suggesting decreased required imaging time.
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