Abstract #0423
13 C MRS of the brain without decoupling
Keshav Datta 1 , Arif Wibowo 2 , Stephen R. Lynch 2 , and Daniel Spielman 3
1
Dept. of Electrical Engineering, Stanford
University, Stanford, CA, United States,
2
Dept.
of Chemistry, Stanford University, CA, United States,
3
Dept.
of Radiology, Stanford University, Stanford, CA, United
States
We propose an improved Proton Observed Carbon Edited
(POCE) method, PROCEED, that eliminates splitting due to
short-range
13
C-
1
H
J-coupling. Although the overall SNR for the PROCEED
method is √2 less than that achieved using a decoupled
POCE acquisition, spectral simplification and reduced
metabolite peak overlap is achieved without
SAR-intensive decoupling. The elimination of decoupling
makes in vivo
13
C
MRS of neuroenergetics and neurotransmitter cycling
potentially viable for studies throughout the human
brain.
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