Abstract #0426
Metabolome profiling by HRMAS NMR spectroscopy of hyperfunctioning parathyroid glands
Stphanie Battini 1 , Alessio Imperiale 1,2 , David Taieb 3 , Karim Elbayed 1 , Frdric Sebag 4 , Laurent Brunaud 5 , and Izzie-Jacques Namer 1,6
1
ICube laboratory UMR 7357, University of
Strasbourg/CNRS and FMTS, Strasbourg, France,
2
University
Hospitals of Strasbourg, Department of Biophysics and
Nuclear Medicine, Hautepierre, Strasbourg, France,
3
La
Timone University Hospital, European Center for Research
in Medical Imaging, Aix-Marseille University, Marseille,
France,
4
Department
of Endocrine Surgery, La Timone University Hospital,
Aix-Marseille University, Marseille, France,
5
Department
of Digestive, Hepato-Biliary and Endocrine Surgery,
Brabois University Hospital, Nancy, France,
6
University
Hospitals of Strasbourg, Department of Biophysics and
Nuclear Medicine, Hautepierre Hospital, Strasbourg,
France
Context: Primary hyperparathyroidism (pHPT) may be
related to a single gland (SGD) or multiglandular
disease (MGD) and is probably related to defects in a
set of specific genes that control parathyroid cell
growth. By contrast, in patients on long-standing
dialysis, parathyroid develop a diffuse hyperplasia and
with time progressively shift to monoclonal growth. The
aim of the present study was to characterize the
metabolomic profiles of parathyroid disorders of
different origin by High Resolution Magic Angle Spinning
(HR-MAS) Nuclear Magnetic Resonance (NMR).
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