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Abstract #0426

Metabolome profiling by HRMAS NMR spectroscopy of hyperfunctioning parathyroid glands

Stphanie Battini 1 , Alessio Imperiale 1,2 , David Taieb 3 , Karim Elbayed 1 , Frdric Sebag 4 , Laurent Brunaud 5 , and Izzie-Jacques Namer 1,6

1 ICube laboratory UMR 7357, University of Strasbourg/CNRS and FMTS, Strasbourg, France, 2 University Hospitals of Strasbourg, Department of Biophysics and Nuclear Medicine, Hautepierre, Strasbourg, France, 3 La Timone University Hospital, European Center for Research in Medical Imaging, Aix-Marseille University, Marseille, France, 4 Department of Endocrine Surgery, La Timone University Hospital, Aix-Marseille University, Marseille, France, 5 Department of Digestive, Hepato-Biliary and Endocrine Surgery, Brabois University Hospital, Nancy, France, 6 University Hospitals of Strasbourg, Department of Biophysics and Nuclear Medicine, Hautepierre Hospital, Strasbourg, France

Context: Primary hyperparathyroidism (pHPT) may be related to a single gland (SGD) or multiglandular disease (MGD) and is probably related to defects in a set of specific genes that control parathyroid cell growth. By contrast, in patients on long-standing dialysis, parathyroid develop a diffuse hyperplasia and with time progressively shift to monoclonal growth. The aim of the present study was to characterize the metabolomic profiles of parathyroid disorders of different origin by High Resolution Magic Angle Spinning (HR-MAS) Nuclear Magnetic Resonance (NMR).

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