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Abstract #0425

Diffusion-Weighted MR Spectroscopy feasibility in clinical studies at 3 T : the effect of reducing the acquisition time investigated by bootstrapping

Francesca Branzoli 1,2 , Daniel Garcia-Lorenzo 1,2 , Romain Valabrgue 1,2 , and Stephane Lehricy 1,2

1 Institut du Cerveau et de la Moelle pinire ICM, Centre de Neuroimagerie de Recherche CENIR, Paris, France, 2 Sorbonnes Universit, Universit Pierre et Marie Curie and Inserm UMR-S1127; CNRS, UMR 7225, Paris, France

Diffusion-weighted MR Spectroscopy (DW-MRS) allows to measure the diffusion properties of intra-cellular metabolites in-vivo, and in recent years it has been proved a powerful tool to investigate brain tissue microstructure and function in both healthy and disease. However, due to the low concentration of brain metabolites, the applicability of DW-MRS in clinical protocols may be prevented by the long acquisition times often required by this technique. In this study, we simulated the variability of the apparent diffusion coefficients (ADCs) of total n-acetylaspartate (tNAA), total creatine (tCr) and choline compounds (tCho) associated with different acquisition schemes of different durations, and propose a short and efficient acquisition protocol to be used in clinical application.

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