Abstract #0430
Dissecting Myelin and Axon Abnormalities in Schizophrenia and Bipolar disorder Patients using Novel MRI Approaches
Fei Du 1 , Eve Lewandowski 1 , Jackie Goldbatch 1 , and Dost Ongur 1
1
McLean Hospital, Harvard Medical School,
Belmont, MA, United States
Schizophrenia (SZ) and Bipolar disorders (BD) are
associated with brain tissue microstructure changes
especially in the white matter (WM), which was commonly
quantified by DTI. However, DTI is difficult to
distinguish abnormalities between axonal and myelin. In
this study, we examined WM integrity using two
complementary MR-based techniques: MTR to probe myelin
content and diffusion tensor spectroscopy (DTS) of NAA
to probe axonal geometry. Our findings suggest SZ and BD
have the distinct different abnormality: SZ is
associated with abnormalities of amount of myelin and
the structure of axons, whereas WM abnormalities in BD
may be specific to myelin.
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