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Abstract #0430

Dissecting Myelin and Axon Abnormalities in Schizophrenia and Bipolar disorder Patients using Novel MRI Approaches

Fei Du 1 , Eve Lewandowski 1 , Jackie Goldbatch 1 , and Dost Ongur 1

1 McLean Hospital, Harvard Medical School, Belmont, MA, United States

Schizophrenia (SZ) and Bipolar disorders (BD) are associated with brain tissue microstructure changes especially in the white matter (WM), which was commonly quantified by DTI. However, DTI is difficult to distinguish abnormalities between axonal and myelin. In this study, we examined WM integrity using two complementary MR-based techniques: MTR to probe myelin content and diffusion tensor spectroscopy (DTS) of NAA to probe axonal geometry. Our findings suggest SZ and BD have the distinct different abnormality: SZ is associated with abnormalities of amount of myelin and the structure of axons, whereas WM abnormalities in BD may be specific to myelin.

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