Abstract #0429
Demyelination versus increased free water in schizophrenia: A pilot study using q-space trajectory imaging
Markus Nilsson 1 , Filip Szczepankiewicz 2 , Danielle van Westen 3 , Cecilia Mattisson 4 , Mats Bogren 4 , Ofer Pasternak 5 , Marek Kubicki 5 , and Carl-Fredrik Westin 5,6
1
Lund University Bioimaging Center, Lund
University, Lund, Sweden,
2
Dept.
of Medical Radiation Physics, Lund University, Lund,
Sweden,
3
Diagnostic
Radiology, Lund University, Lund, Sweden,
4
Clinical
Sciences, Psychiatry, Lund University, Lund, Sweden,
5
Brigham
and Womens Hospital, Harvard Medical School, MA, United
States,
6
Dept.
of Biomedical Engineering, Linkping University,
Linkping, Sweden
In this work, we estimate the second and fourth moments,
i.e. the mean (2nd order tensor) and the covariance (4th
order tensor) of a distribution of tensors. Estimation
of the covariance tensor is not possible with
conventional diffusion encoding, but was enabled by
q-space trajectory imaging (QTI). We compare novel
invariant scalar quantities of the 4th order tensor
between schizophrenia patients and healthy controls, and
conclude that the changes observed in schizophrenia are
not well explained by elevated radial diffusivity, e.g.
cellular pathology such as demyelination, but very well
by increased levels of free water, e.g. axonal loss or
atrophy.
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