Meeting Banner
Abstract #0436

Relationship Between Structure and Function of the Auditory System is Altered in 16p11.2 Deletion and Duplication

Jeffrey I Berman 1,2 , Julian Jenkins 1 , Darina Chudnovskaya 1 , Srikantan Nagarajan 3 , Pratik Mukherjee 3 , Randy Buckner 4 , John E Spiro 5 , Wendy K Chung 6 , Elliott H Sherr 7 , and Timothy PL Roberts 1,2

1 Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States, 2 Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 3 Radiology, University of California San Francisco, California, United States, 4 Psychology, Harvard University, Boston, Massachusetts, United States, 5 Simons Foundation, New York, United States, 6 Pediatrics and Medicine, Columbia University Medical Center, New York, United States, 7 Neurology, University of California San Francisco, California, United States

Deletion and duplication of chromosome 16p11.2has been associated with developmental disorders such as autism spectrum disorders (ASD). This multimodal study hypothesizes that the relationship between auditory radiation microstructure and the timing of the auditory evoked response (M100) is altered in children with 16p11.2 deletions and duplications. Diffusion MR and MEG were performed on 39 controls, 30 deletion carriers, and 9 duplication carriers. In the controls, low M100 was significantly correlated with low diffusivity. In the deletion and duplication populations, no significant correlation between DTI metrics and M100 was observed. This multimodal study indicates varying gene doses may similarly have an abnormal structure-function relationship.

This abstract and the presentation materials are available to members only; a login is required.

Join Here