Abstract #0437
Symptom-based subtypes of major depressive disorder manifest distinct nucleus accumbens hemodynamic responses to reward and punishment
Masaya Misaki 1 , Teresa Victor 1 , Hideo Suzuki 1 , Kent Teague 2 , Brett McKinney 3 , Jonathan Savitz 1,4 , Wayne Drevets 1,5 , and Jerzy Bodurka 1,6
1
Laureate Institute for Brain Research,
Tulsa, OK, United States,
2
Dept.
of Surgery, University of Oklahoma College of Medicine,
OK, United States,
3
Tandy
School of Computer Science, Dept. of Mathematics,
University of Tulsa, OK, United States,
4
Dept.
of Medicine, Tulsa School of Community Medicine,
University of Tulsa, OK, United States,
5
Janssen
Pharmaceuticals, LLC, of Johnson & Johnson, Inc.,
Titusville, NJ, United States,
6
College
of Engineering, University of Oklahoma, OK, United
States
Distinct patterns of hemodynamic responses of the
nucleus accumbens (NAcc) to gains and losses exist in
healthy and depressed subjects. We identified
associations between subtypes of reward- and
punishment-related responses in NAcc and specific
depressive symptoms. Linear discriminant analysis was
performed on individual symptom ratings from the HAM-A,
HAM-D and MADRS. Lower hemodynamic activity in NAcc
correlated with more severe symptoms in
Depersonalization and Derealization, Suicidal
thoughts, and Anxiety Somatic items. Elevated NAcc
activity correlated with more severe symptoms in
Depressed mood and Inability to feel domains.
Patients with normal NAcc responses (most healthy
subjects) manifested no or mild symptoms.
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