Meeting Banner
Abstract #0437

Symptom-based subtypes of major depressive disorder manifest distinct nucleus accumbens hemodynamic responses to reward and punishment

Masaya Misaki 1 , Teresa Victor 1 , Hideo Suzuki 1 , Kent Teague 2 , Brett McKinney 3 , Jonathan Savitz 1,4 , Wayne Drevets 1,5 , and Jerzy Bodurka 1,6

1 Laureate Institute for Brain Research, Tulsa, OK, United States, 2 Dept. of Surgery, University of Oklahoma College of Medicine, OK, United States, 3 Tandy School of Computer Science, Dept. of Mathematics, University of Tulsa, OK, United States, 4 Dept. of Medicine, Tulsa School of Community Medicine, University of Tulsa, OK, United States, 5 Janssen Pharmaceuticals, LLC, of Johnson & Johnson, Inc., Titusville, NJ, United States, 6 College of Engineering, University of Oklahoma, OK, United States

Distinct patterns of hemodynamic responses of the nucleus accumbens (NAcc) to gains and losses exist in healthy and depressed subjects. We identified associations between subtypes of reward- and punishment-related responses in NAcc and specific depressive symptoms. Linear discriminant analysis was performed on individual symptom ratings from the HAM-A, HAM-D and MADRS. Lower hemodynamic activity in NAcc correlated with more severe symptoms in Depersonalization and Derealization, Suicidal thoughts, and Anxiety Somatic items. Elevated NAcc activity correlated with more severe symptoms in Depressed mood and Inability to feel domains. Patients with normal NAcc responses (most healthy subjects) manifested no or mild symptoms.

This abstract and the presentation materials are available to members only; a login is required.

Join Here