The effect of macroscopic field gradients on the simultaneous estimation of reversible and irreversible transverse relaxation rates

Pulse sequences such as GESFIDE and GESSE have enabled the simultaneous measurement of irreversible and reversible transverse relaxation rates. Reversible relaxation is influenced by both macroscopic and mesoscopic field inhomogeneities, with considerable interest in separating effects of the former from the latter. Here, we applied linear macroscopic gradients during GESSE scans of the knee, where significant mesoscopic field variations are induced by bone trabeculae. We find that the sinc-term corrections that have been proposed are not warranted and that the recently-observed Gaussian behavior of GESSE time-domain signals provides a better avenue for factoring out the effects of macroscopic field variations.

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