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Abstract #0459

Ferumoxytol Enhanced T 2 * Mapping for Combined Renal Oxygenation and Blood Volume Assessment at 9.4T

Andreas Pohlmann 1 , Karen Arakelyan 1 , Till Huelnhagen 1 , Kathleen Cantow 2 , Stefanie Kox 1 , Yvonne Balke 1 , Bert Flemming 2 , Erdmann Seeliger 2 , and Thoralf Niendorf 1,3

1 Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2 Institute of Physiology and Center for Cardiovascular Research, Charite-Universitaetsmedizin Berlin, Berlin, Germany, 3 Experimental and Clinical Research Center, Charite-Universitaetsmedizin Berlin, Berlin, Germany

Acute kidney injuries are often characterized by tissue oxygen hypoxia. T2*-mapping permits probing renal oxygenation but provides a surrogate rather than a quantitative measure of oxygen saturation. The link between tissue pO2 and T2* is influenced by changes in vascular volume fraction. Use of ferumoxytol could permit RBV assessment, which may be essential for unambiguous interpretation of renal T2*. To determine a suitable ferumoxytol dose we combined simulation-based error estimation with in vivo data for doses of 0-10mg Fe/kg during baseline and venous occlusion. Ferumoxytol dose finding was based on the relation of the noise-induced T2*-error to the occlusion-induced T2*-change.

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