Abstract #0459
Ferumoxytol Enhanced T 2 * Mapping for Combined Renal Oxygenation and Blood Volume Assessment at 9.4T
Andreas Pohlmann 1 , Karen Arakelyan 1 , Till Huelnhagen 1 , Kathleen Cantow 2 , Stefanie Kox 1 , Yvonne Balke 1 , Bert Flemming 2 , Erdmann Seeliger 2 , and Thoralf Niendorf 1,3
1
Berlin Ultrahigh Field Facility, Max
Delbrueck Center for Molecular Medicine, Berlin,
Germany,
2
Institute
of Physiology and Center for Cardiovascular Research,
Charite-Universitaetsmedizin Berlin, Berlin, Germany,
3
Experimental
and Clinical Research Center,
Charite-Universitaetsmedizin Berlin, Berlin, Germany
Acute kidney injuries are often characterized by tissue
oxygen hypoxia. T2*-mapping permits probing renal
oxygenation but provides a surrogate rather than a
quantitative measure of oxygen saturation. The link
between tissue pO2 and T2* is influenced by changes in
vascular volume fraction. Use of ferumoxytol could
permit RBV assessment, which may be essential for
unambiguous interpretation of renal T2*. To determine a
suitable ferumoxytol dose we combined simulation-based
error estimation with in vivo data for doses of 0-10mg
Fe/kg during baseline and venous occlusion. Ferumoxytol
dose finding was based on the relation of the
noise-induced T2*-error to the occlusion-induced
T2*-change.
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