Abstract #0460
Detection of macrophage-based inflammation following renal ischemia reperfusion injuries using super-paramagnetic iron oxide (SPIO) nanoparticles in T2-weighted MRI.
B G Hammond 1 , J C Montejano 2 , J M Poth 2 , K M Huber 2 , M Stukova 2 , D Golovko 3 , and N J Serkova 2
1
University of Arizona College of Medicine -
Phoenix, Phoenix, Arizona, United States,
2
University
of Colorado Anschutz Medical Campus, Aurora, Colorado,
United States,
3
Good
Samaritan Medical Center, Massachusetts, United States
Following renal ischemia, reperfusion injuries occur,
mediated by a macrophage inflammatory response. Due to
the role of macrophages in iron metabolism it is
possible to image inflammation using iron oxide nano
particles (SPIONs) and T2w-MRI. In this study, acute
kidney injury was induced in 10 female C57 mice by
clamping the renal artery. Clodronate (CLD) driven
macrophage depletion was attempted. In developing this
protocol, we have shown that CLD is not an appropriate
agent to deplete macrophages in the kidney and that
24hours is not an appropriate time point to assess
macrophages using SPION T2-MRI due to their disturbed
kinetics.
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