Abstract #0461
Relating Iodixanol-Induced Renal T 2 * Changes to Tissue pO 2 by Comparison with Near-Infrared Spectroscopy and Invasive Physiological Measurements
Andreas Pohlmann 1 , Karen Arakelyan 1,2 , Dirk Grosenick 3 , Kathleen Cantow 2 , Heidrun Wabnitz 3 , Bert Flemming 2 , Rainer Macdonald 3 , Erdmann Seeliger 2 , and Thoralf Niendorf 1,4
1
Berlin Ultrahigh Field Facility, Max
Delbrueck Center for Molecular Medicine, Berlin,
Germany,
2
Institute
of Physiology and Center for Cardiovascular Research,
Charite-Universitaetsmedizin Berlin, Berlin, Germany,
3
Physikalisch-Technische
Bundesanstalt (PTB), Berlin, Germany,
4
Experimental
and Clinical Research Center,
Charite-Universitaetsmedizin Berlin, Berlin, Germany
Renal tissue hypoxia is a key element in the
pathophysiology of x-ray contrast media (CM) induced
acute kidney injury. T2* mapping permits non-invasive
probing of renal oxygenation. There is some discrepancy
between reported CM effects on T2* and tissue pO2.
Bridging the gap between tissue pO2 measured by invasive
physiological methods (PHYSIOL) and T2*, near-infrared
spectroscopy (NIRS) provides access to Hb concentration
per tissue volume and oxygen saturation of Hb crucial
parameters for interpretation of renal T2*. We studied
the effects of intra-arterial injection of iodixanol, a
high viscosity x-ray CM, by combining data obtained from
MRI, NIRS and PHYSIOL.
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