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Abstract #0461

Relating Iodixanol-Induced Renal T 2 * Changes to Tissue pO 2 by Comparison with Near-Infrared Spectroscopy and Invasive Physiological Measurements

Andreas Pohlmann 1 , Karen Arakelyan 1,2 , Dirk Grosenick 3 , Kathleen Cantow 2 , Heidrun Wabnitz 3 , Bert Flemming 2 , Rainer Macdonald 3 , Erdmann Seeliger 2 , and Thoralf Niendorf 1,4

1 Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2 Institute of Physiology and Center for Cardiovascular Research, Charite-Universitaetsmedizin Berlin, Berlin, Germany, 3 Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, 4 Experimental and Clinical Research Center, Charite-Universitaetsmedizin Berlin, Berlin, Germany

Renal tissue hypoxia is a key element in the pathophysiology of x-ray contrast media (CM) induced acute kidney injury. T2* mapping permits non-invasive probing of renal oxygenation. There is some discrepancy between reported CM effects on T2* and tissue pO2. Bridging the gap between tissue pO2 measured by invasive physiological methods (PHYSIOL) and T2*, near-infrared spectroscopy (NIRS) provides access to Hb concentration per tissue volume and oxygen saturation of Hb crucial parameters for interpretation of renal T2*. We studied the effects of intra-arterial injection of iodixanol, a high viscosity x-ray CM, by combining data obtained from MRI, NIRS and PHYSIOL.

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