Abstract #0462
Measuring Single Nephron Filtration with Molecular MRI
Edwin J Baldelomar 1 , Jennifer Charlton 2 , and Kevin M. Bennett 3
1
Physics, University of Hawaii at Manoa,
Honolulu, Hawaii, United States,
2
University
of Virginia, Virginia, United States,
3
Biology,
University of Hawaii at Manoa, Hawaii, United States
Here we investigated the use of two MRI contrast agents,
cationic ferritin (CF) and gd-DTPA, to measure local
macromolecular filtration and glomerular filtration
rates in 3D MRI at voxel resolution in isolated,
perfused rat kidneys under physiological conditions. CF
is a glomerulus-specific, superparamagentic targeted
nanoparticle (*ref), and gd-DTPA is eliminated through
the tubule. CF uptake rate was thus measured dynamically
as a marker for macromolecular filtration, and Gd-DTPA
passage was used as a marker for local (voxel)
glomerular filtration.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
