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Abstract #0462

Measuring Single Nephron Filtration with Molecular MRI

Edwin J Baldelomar 1 , Jennifer Charlton 2 , and Kevin M. Bennett 3

1 Physics, University of Hawaii at Manoa, Honolulu, Hawaii, United States, 2 University of Virginia, Virginia, United States, 3 Biology, University of Hawaii at Manoa, Hawaii, United States

Here we investigated the use of two MRI contrast agents, cationic ferritin (CF) and gd-DTPA, to measure local macromolecular filtration and glomerular filtration rates in 3D MRI at voxel resolution in isolated, perfused rat kidneys under physiological conditions. CF is a glomerulus-specific, superparamagentic targeted nanoparticle (*ref), and gd-DTPA is eliminated through the tubule. CF uptake rate was thus measured dynamically as a marker for macromolecular filtration, and Gd-DTPA passage was used as a marker for local (voxel) glomerular filtration.

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