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Abstract #0463

Susceptibility tensor imaging reveals reduced anisotropy in renal nephropathy

Luke Xie 1 , Russell Dibb 1,2 , Susan B. Gurley 3 , Chunlei Liu 1,4 , and G. Allan Johnson 1,2

1 Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, United States, 2 Biomedical Engineering, Duke University, Durham, North Carolina, United States, 3 Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, United States, 4 Brain Imaging Analysis Center, Duke University Medical Center, Durham, North Carolina, United States

In normal kidneys, DTI and susceptibility tensor imaging (STI) can detect and track tubules in the inner medulla. We investigated whether STI can be more sensitive than DTI in models of renal nephropathy (angiotensin receptor knockout and diabetic nephropathy). We found that DTI fractional anisotropy and tractography exhibited some changes in the inner medulla of diseased kidneys. STI, on the other hand, had significantly reduced anisotropy and virtually did not track any tubules in the inner medulla. STI therefore was more sensitive to injury in renal tubules.

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