Abstract #0463
Susceptibility tensor imaging reveals reduced anisotropy in renal nephropathy
Luke Xie 1 , Russell Dibb 1,2 , Susan B. Gurley 3 , Chunlei Liu 1,4 , and G. Allan Johnson 1,2
1
Center for In Vivo Microscopy, Duke
University Medical Center, Durham, North Carolina,
United States,
2
Biomedical
Engineering, Duke University, Durham, North Carolina,
United States,
3
Division
of Nephrology, Department of Medicine, Duke University
and Durham VA Medical Centers, Durham, North Carolina,
United States,
4
Brain
Imaging Analysis Center, Duke University Medical Center,
Durham, North Carolina, United States
In normal kidneys, DTI and susceptibility tensor imaging
(STI) can detect and track tubules in the inner medulla.
We investigated whether STI can be more sensitive than
DTI in models of renal nephropathy (angiotensin receptor
knockout and diabetic nephropathy). We found that DTI
fractional anisotropy and tractography exhibited some
changes in the inner medulla of diseased kidneys. STI,
on the other hand, had significantly reduced anisotropy
and virtually did not track any tubules in the inner
medulla. STI therefore was more sensitive to injury in
renal tubules.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
