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Abstract #0470

TractCaliber: Axon diameter estimation across white matter tracts in the in vivo human brain using 300 mT/m gradients

Susie Y. Huang 1 , Thomas Witzel 1 , Qiuyun Fan 1 , Jennifer A. McNab 2 , Lawrence L. Wald 1,3 , and Aapo Nummenmaa 1

1 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2 Radiological Sciences Laboratory, Department of Radiology, Stanford University, Stanford, CA, United States, 3 Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

The characterization of white matter pathways by diffusion tractography could be improved by incorporating quantitative information on axonal size provided by axon diameter mapping methods. We demonstrate axon diameter estimation across white matter tracts of arbitrary orientation in the in vivo human brain using gradient strengths up to 300 mT/m. TractCaliber offers consistent axon diameter estimates across the corpus callosum and corticospinal tracts that agree with histological observations, thereby supporting the use of high gradient strengths for accurate in vivo estimation of axon diameters across white matter tracts.

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