TractCaliber: Axon diameter estimation across white matter tracts in the in vivo human brain using 300 mT/m gradients
Susie Y. Huang 1 , Thomas Witzel 1 , Qiuyun Fan 1 , Jennifer A. McNab 2 , Lawrence L. Wald 1,3 , and Aapo Nummenmaa 1
Athinoula A. Martinos Center for Biomedical
Imaging, Department of Radiology, Massachusetts General
Hospital, Charlestown, MA, United States,
Sciences Laboratory, Department of Radiology, Stanford
University, Stanford, CA, United States,
Division of Health Sciences and Technology,
Massachusetts Institute of Technology, Cambridge, MA,
The characterization of white matter pathways by
diffusion tractography could be improved by
incorporating quantitative information on axonal size
provided by axon diameter mapping methods. We
demonstrate axon diameter estimation across white matter
tracts of arbitrary orientation in the in vivo human
brain using gradient strengths up to 300 mT/m.
TractCaliber offers consistent axon diameter estimates
across the corpus callosum and corticospinal tracts that
agree with histological observations, thereby supporting
the use of high gradient strengths for accurate in vivo
estimation of axon diameters across white matter tracts.
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