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Abstract #0473

Localizing and characterizing single fiber populations throughout the brain

Chantal M.W. Tax 1 , Dmitry S. Novikov 2 , Eleftherios Garyfallidis 3 , Max A. Viergever 1 , Maxime Descoteaux 3 , and Alexander Leemans 1

1 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Center for Biomedical Imaging, New York University School of Medicine, New York, New York, United States, 3 Sherbrooke Connectivity Imaging Lab, Universit de Sherbrooke, Sherbrooke, Quebec, Canada

In this work we localize single fiber population (SFP) voxels in the brain by recursively excluding crossing fiber voxels with constrained spherical deconvolution in multi-shell diffusion MRI data. We investigate the average signal decay over all SFPs parallel and perpendicular to the fiber, and extract (microstructural) diffusion indices by fitting various models. By doing so, we have characterized SFPs throughout the brain and in different tracts, which can potentially be used as reference for healthy brain in group studies or simulation studies.

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