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Abstract #0472

Improving the interpretation of diffusional kurtosis by resolving effects of isotropic and anisotropic microstructures

Filip Szczepankiewicz 1 , Danielle van Westen 2,3 , Jimmy Ltt 2 , Elisabet Englund 3 , Carl-Fredrik Westin 4 , Freddy Sthlberg 1,3 , Pia C. Sundgren 2,3 , and Markus Nilsson 5

1 Dept. of Medical Radiation Physics, Lund University, Lund, Sweden, 2 Imaging and Function, Skne University Healthcare, Lund, Sweden, 3 Dept. of Clinical Sciences, Lund University, Skne University Healthcare, Lund, Sweden, 4 Dept. of Radiology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, United States, 5 Lund University Bioimaging Center, Lund University, Lund, Sweden

In this work we separate diffusional kurtosis into components rendered by isotropic and anisotropic microstructural features, by combining conventional and single-shot isotropic diffusion encoding. We show that glioma and meningioma tumors exhibit two radically different origins of kurtosity in vivo. This indicates that the gliomas and meningiomas contain isotropic domains with varying diffusivity, and randomly oriented anisotropic domains, respectively. Finally, we conclude that disentangling the origins of diffusional kurtosis improves the sensitivity and specificity of kurtosis parameters as well as the ability to interpret such parameters.

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