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Abstract #0478

Human in vivo myeloarchitecture using whole-brain diffusion MRI

Fernando Calamante 1 , Ben Jeurissen 2 , Robert Elton Smith 1 , Jacques-Donald Tournier 3,4 , and Alan Connelly 1

1 The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia, 2 iMinds-Vision Lab, Dept. of Physics, University of Antwerp, Belgium, 3 Centre for the Developing Brain, King's College London, London, United Kingdom, 4 Department of Biomedical Engineering, King's College London, London, United Kingdom

Non-invasive mapping of cortical myeloarchitecture has received increasing interest, with MRI methods based on T1/T2/T2*-weighting producing detailed cortical maps based on myelin content. Recent improvements in hardware, acquisition, and analysis methods make diffusion MRI a promising tool for studying myeloarchitecture. We combine high-quality data and recent advances in fibre-orientation modelling to investigate myeloarchitecture in the living human whole-brain. We show cortical patterns similar to those found with other methods, including well-defined areas in the sensory-motor strip, visual cortex, and auditory areas, among others. In vivo human diffusion MRI data should therefore provide a useful complementary approach to study whole-brain myeloarchitecture.

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