Abstract #0478
Human in vivo myeloarchitecture using whole-brain diffusion MRI
Fernando Calamante 1 , Ben Jeurissen 2 , Robert Elton Smith 1 , Jacques-Donald Tournier 3,4 , and Alan Connelly 1
1
The Florey Institute of Neuroscience and
Mental Health, University of Melbourne, Melbourne,
Victoria, Australia,
2
iMinds-Vision
Lab, Dept. of Physics, University of Antwerp, Belgium,
3
Centre
for the Developing Brain, King's College London, London,
United Kingdom,
4
Department
of Biomedical Engineering, King's College London,
London, United Kingdom
Non-invasive mapping of cortical myeloarchitecture has
received increasing interest, with MRI methods based on
T1/T2/T2*-weighting producing detailed cortical maps
based on myelin content. Recent improvements in
hardware, acquisition, and analysis methods make
diffusion MRI a promising tool for studying
myeloarchitecture. We combine high-quality data and
recent advances in fibre-orientation modelling to
investigate myeloarchitecture in the living human
whole-brain. We show cortical patterns similar to those
found with other methods, including well-defined areas
in the sensory-motor strip, visual cortex, and auditory
areas, among others. In vivo human diffusion MRI data
should therefore provide a useful complementary approach
to study whole-brain myeloarchitecture.
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