Abstract #0480
Multimodal MR/PET imaging for characterization of hypoxia in human glioblastoma
Christine Preibisch 1,2 , Mathias Lukas 3 , Anne Kluge 1 , Severin Keinath 3 , Vivien Tth 1,4 , Kuangyu Shi 3 , Thomas Pyka 3 , and Stefan Frster 3
1
Department of Neuroradiology, Klinikum
rechts der Isar der TU Mnchen, Munich, Germany,
2
Clinic
for Neurology, Klinikum rechts der Isar der TU Mnchen,
Munich, Germany,
3
Department
of Nuclear Medicine, Klinikum rechts der Isar der TU
Mnchen, Munich, Germany,
4
Department
of Radiology, Klinikum rechts der Isar der TU Mnchen,
Munich, Germany
Preliminary multimodal MR/PET data from 18 patients with
glioblastoma are presented with the aim of a
comprehensive characterization of tumor pathophysiology.
A semi-quantitative BOLD-based parameter, related to
vascular de-oxygenation, termed relative oxygen
extraction fraction (rOEF), was acquired simultaneously
with 18F-FET PET, which has been shown to be valuable
for detecting highly malignant tumor tissue. In a small
subgroup of four patients, hypoxia related 18F-FMISO PET
was acquired. These preliminary data support the utility
of 18F-FET and rCBV as markers for viable malignant
tumor tissue. With respect to hypoxia, more patient data
and more sophisticated analyses are clearly needed.
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