Abstract #0484
pH-Weighted Molecular MRI in Brain Tumors
Benjamin M Ellingson 1,2 , Robert J Harris 3 , William H Yong 4 , Whitney Pope 3 , Debiao Li 5 , Linda M Liau 6 , and Timothy F Cloughesy 7
1
Radiology, UCLA, Los Angeles, CA, United
States,
2
Psychiatry
& Biobehavioral Sciences, UCLA, CA, United States,
3
Radiology,
UCLA, CA, United States,
4
Pathology, UCLA, CA,
United States,
5
Biomedical
Sciences and Imaging, Cedars-Sinai Medical Center, CA,
United States,
6
Neurosurgery,
UCLA, CA, United States,
7
Neurology,
UCLA, CA, United States
A decrease in pH within the tumor microenvironment
results in malignant transformation, resistance to
radiation therapy, resistance to specific
chemotherapies, increased probability of metastasis,
immunosuppression, increased tumor invasion, increased
rate of mutation, increased chromosomal rearrangements,
altered gene expression, and angiogenesis. A
non-invasive imaging method for evaluating tumor tissue
pH will be valuable for early detection of treatment
response, tumor progression, and/or treatment failure in
malignant tumors. Our preliminary data suggests that
chemical exchange saturation transfer (CEST) imaging, a
new MRI technique, can be used to identify tumor tissue
with low pH (acidic tissue) by targeting MR excitation
of amine protons on glutamine, a major source of fuel
for tumor cells.
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