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Abstract #0484

pH-Weighted Molecular MRI in Brain Tumors

Benjamin M Ellingson 1,2 , Robert J Harris 3 , William H Yong 4 , Whitney Pope 3 , Debiao Li 5 , Linda M Liau 6 , and Timothy F Cloughesy 7

1 Radiology, UCLA, Los Angeles, CA, United States, 2 Psychiatry & Biobehavioral Sciences, UCLA, CA, United States, 3 Radiology, UCLA, CA, United States, 4 Pathology, UCLA, CA, United States, 5 Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, CA, United States, 6 Neurosurgery, UCLA, CA, United States, 7 Neurology, UCLA, CA, United States

A decrease in pH within the tumor microenvironment results in malignant transformation, resistance to radiation therapy, resistance to specific chemotherapies, increased probability of metastasis, immunosuppression, increased tumor invasion, increased rate of mutation, increased chromosomal rearrangements, altered gene expression, and angiogenesis. A non-invasive imaging method for evaluating tumor tissue pH will be valuable for early detection of treatment response, tumor progression, and/or treatment failure in malignant tumors. Our preliminary data suggests that chemical exchange saturation transfer (CEST) imaging, a new MRI technique, can be used to identify tumor tissue with low pH (acidic tissue) by targeting MR excitation of amine protons on glutamine, a major source of fuel for tumor cells.

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