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Abstract #0485

Applying a length and offset varied saturation (LOVARS) CEST method for Imaging Cerebral Glioma

Xiaolei Song 1 , Yan Bai 2 , Erning Zhang 2 , Xiaowei He 1,3 , Panli Zuo 4 , Dapeng Shi 2 , Michael T. McMahon 1 , Benjamin Schmitt 5 , and Meiyun Wang 2

1 The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, 2 Department of Radiology, Henan Provincial Peoples Hospital, Zhengzhou, Henan, China, 3 School of Information Sciences and Technology, Northwest University, Xi'an, Shaanxi, China, 4 MR Collaborations NE Asia, Siemens Healthcare, Beijing, China, 5 Healthcare Sector, Siemens Ltd Australia, Macquarie Park, Australia

We integrated a length and offset varied saturation (LOVARS) CEST method on a 3.0T MR scanner for improved APT imaging on patients with gliomas. Instead of sweeping different frequency offsets as conventional APT imaging, the LOVARS scheme collects only 2 offsets with different pre-saturation time for 3-4 cycles for improving CNR efficiency. In multiple patients with cerebral gliomas confirmed by histopathology, LOVARS phase maps clearly show improved CNR and well-defined tumor boundary, also reducing the total scan time and SAR effect. In addition, the phase contrast showed differences between patients, which may allow differentiation of tumor types as APT.

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