Abstract #0485
Applying a length and offset varied saturation (LOVARS) CEST method for Imaging Cerebral Glioma
Xiaolei Song 1 , Yan Bai 2 , Erning Zhang 2 , Xiaowei He 1,3 , Panli Zuo 4 , Dapeng Shi 2 , Michael T. McMahon 1 , Benjamin Schmitt 5 , and Meiyun Wang 2
1
The Russell H. Morgan Department of
Radiology and Radiological Science, The Johns Hopkins
University, Baltimore, MD, United States,
2
Department
of Radiology, Henan Provincial Peoples Hospital,
Zhengzhou, Henan, China,
3
School
of Information Sciences and Technology, Northwest
University, Xi'an, Shaanxi, China,
4
MR
Collaborations NE Asia, Siemens Healthcare, Beijing,
China,
5
Healthcare
Sector, Siemens Ltd Australia, Macquarie Park, Australia
We integrated a length and offset varied saturation
(LOVARS) CEST method on a 3.0T MR scanner for improved
APT imaging on patients with gliomas. Instead of
sweeping different frequency offsets as conventional APT
imaging, the LOVARS scheme collects only 2 offsets with
different pre-saturation time for 3-4 cycles for
improving CNR efficiency. In multiple patients with
cerebral gliomas confirmed by histopathology, LOVARS
phase maps clearly show improved CNR and well-defined
tumor boundary, also reducing the total scan time and
SAR effect. In addition, the phase contrast showed
differences between patients, which may allow
differentiation of tumor types as APT.
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