Abstract #0500
Assessment of cortical porosity at 11.7 T and its correlation with CT porosity and biomechanics
Robert Nikolov 1 , Jun Chen 1 , Won Bae 1 , Reni Biswas 1 , Robert Healey 1 , Eric Chang 1,2 , Christine Chung 1,2 , Graeme Bydder 1 , and Jiang Du 1
1
Radiology, University of California, San
Diego, San Diego, California, United States,
2
Radiology,
VA San Diego Healthcare System, La Jolla, California,
United States
Conventional long echo time (TE) imaging sequences are
not applicable to short T2 tissues such as cortical
bone. However, through use of high resolution imaging
afforded by 11.7T we are able to detect water found in
the pores of cortical human bone and measure pore sizes
and water fraction which correlate to: cortical porosity
(CT), bound/unbound water ratio using UTE-MT (3T), and
biomechanical properties. Average porosity (CT)
correlates positively with percent water content (R
2
=
0.47 ; p<0.001) and clusters of 5 voxels corresponding
to a pore size of 8000 m
2
(R
2
=
0.62 ; p<0.001).
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