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Abstract #0500

Assessment of cortical porosity at 11.7 T and its correlation with CT porosity and biomechanics

Robert Nikolov 1 , Jun Chen 1 , Won Bae 1 , Reni Biswas 1 , Robert Healey 1 , Eric Chang 1,2 , Christine Chung 1,2 , Graeme Bydder 1 , and Jiang Du 1

1 Radiology, University of California, San Diego, San Diego, California, United States, 2 Radiology, VA San Diego Healthcare System, La Jolla, California, United States

Conventional long echo time (TE) imaging sequences are not applicable to short T2 tissues such as cortical bone. However, through use of high resolution imaging afforded by 11.7T we are able to detect water found in the pores of cortical human bone and measure pore sizes and water fraction which correlate to: cortical porosity (CT), bound/unbound water ratio using UTE-MT (3T), and biomechanical properties. Average porosity (CT) correlates positively with percent water content (R 2 = 0.47 ; p<0.001) and clusters of 5 voxels corresponding to a pore size of 8000 m 2 (R 2 = 0.62 ; p<0.001).

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