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Abstract #0503

Imaging of Grafted Mesenchymal Stem Cells in Bone Tissue

Sergey Magnitsky 1 , Geetha Mohan 1 , Curtis Corum 2 , Djaudat Idiyatullin 2 , Nancy Lane 3 , and Sharmila Majumdar 1

1 Radiology, UCSF, San Francisco, CA, United States, 2 Radiology, University of Minnesota, MN, United States, 3 UC Davis, CA, United States

Mesenchymal stem cells (MSCs) have high potential for a treatment of bone loss disease. Progress in this promising area of research will require an in vivo technique to observe the grafted cells and engraftment pattern overtime. We implemented SWIFT pulse sequence to develop an in vivo imaging protocol to monitor MSC engraftment in the bone tissue. Our preliminary experiments have shown that SWIFT pulse sequence allowed to generate a positive MR signal from iron labeled cells and detect grafted cells in cortical bones. Proposed method will have a profound impact on stem cell treatment of bone degenerative diseases.

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