Abstract #0503
Imaging of Grafted Mesenchymal Stem Cells in Bone Tissue
Sergey Magnitsky 1 , Geetha Mohan 1 , Curtis Corum 2 , Djaudat Idiyatullin 2 , Nancy Lane 3 , and Sharmila Majumdar 1
1
Radiology, UCSF, San Francisco, CA, United
States,
2
Radiology,
University of Minnesota, MN, United States,
3
UC
Davis, CA, United States
Mesenchymal stem cells (MSCs) have high potential for a
treatment of bone loss disease. Progress in this
promising area of research will require an in vivo
technique to observe the grafted cells and engraftment
pattern overtime. We implemented SWIFT pulse sequence to
develop an in vivo imaging protocol to monitor MSC
engraftment in the bone tissue. Our preliminary
experiments have shown that SWIFT pulse sequence allowed
to generate a positive MR signal from iron labeled cells
and detect grafted cells in cortical bones. Proposed
method will have a profound impact on stem cell
treatment of bone degenerative diseases.
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