18F-FDG and 18F-NaF PET/MR Imaging of Osteoarthritis in the Knee: Considerations and Initial Results

New hybrid PET/MR systems allow for simultaneous, sensitive, and quantitative assessments of early bone activity in osteoarthritis (OA) with PET, which can be correlated with high-resolution quantitative MR methods of other tissues to study the pathogenesis of OA We demonstrate initial results of simultaneous time-of-flight PET/MR hybrid imaging of the knee OA. Results suggest that PET/MR may detect knee abnormalities unseen on MRI alone and is a promising tool for early detection of OA change in the bone.

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