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Abstract #0523

Ethanolamine Kinase-1 is the major contributor to Phosphoethanolamine Levels in Breast Cancer Cells

Tariq Shah 1 , Balaji Krishnamachary 1 , Flonne Wildes 1 , Jannie Wijnen 2 , Kristine Glunde 1 , and Zaver M Bhujwalla 1

1 Division of Cancer Imaging Research, Johns Hopkins University, Baltimore, Maryland, United States, 2 University Medical Centre Utrecht, Cancer center, Utrecht, Netherlands

In understanding the aberrant choline metabolism of cancer significant effort has been focused on phosphocholine (PC) but the role of phosphoethanolamine (PE) is relatively underexplored even though tumors show increased PE as consistently as increased PC. Here we have used siRNAs to silence specific genes involved in choline and ethanolamine metabolism to understand their roles in intracellular metabolite levels measured with high-resolution 31P MR spectroscopy of cell extracts. We have demonstrated that ethanolamine kinase-1 (EthnK-1) is the major contributor to PE levels observed in vivo and may be a potential therapeutic target.

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