Abstract #0523
Ethanolamine Kinase-1 is the major contributor to Phosphoethanolamine Levels in Breast Cancer Cells
Tariq Shah 1 , Balaji Krishnamachary 1 , Flonne Wildes 1 , Jannie Wijnen 2 , Kristine Glunde 1 , and Zaver M Bhujwalla 1
1
Division of Cancer Imaging Research, Johns
Hopkins University, Baltimore, Maryland, United States,
2
University
Medical Centre Utrecht, Cancer center, Utrecht,
Netherlands
In understanding the aberrant choline metabolism of
cancer significant effort has been focused on
phosphocholine (PC) but the role of phosphoethanolamine
(PE) is relatively underexplored even though tumors show
increased PE as consistently as increased PC. Here we
have used siRNAs to silence specific genes involved in
choline and ethanolamine metabolism to understand their
roles in intracellular metabolite levels measured with
high-resolution 31P MR spectroscopy of cell extracts. We
have demonstrated that ethanolamine kinase-1 (EthnK-1)
is the major contributor to PE levels observed in vivo
and may be a potential therapeutic target.
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