Abstract #0522
Metabolic signatures of colorectal cancer in biofluids: NMR-based metabolomics of fecal extracts
Yan Lin 1 , Changchun Ma 2 , Zhiwei Shen 1 , zhening wang 1 , and Renhua Wu 1
1
Radiology Department, Second Affiliated
Hospital, Shantou University Medical College, Shantou
City, Guangdong Province, China,
2
Radiation
Oncology, Cancer Hospital, Shantou University Medical
College, Guangdong Province, China
This present study is a NMR-based metabolomics
approaches coupled with orthogonal projection to least
squares discriminant analysis (OPLS-DA) to evaluate the
ability to characterize the metabolic fingerprint of
fecal extracts from patients with colorectal cancer (CRC)
on larger patient cohorts. The most significant
metabolites for classification include short-chain fatty
acids, alanine, isoleucine, leucine, valine, glutamate,
glycerol, suggesting changes in the gut microbial
community or malabsorption. These results shows the
valuable potential of NMR-based metabonomics of fecal
extracts to characterize the systemic metabolic
disturbances underlying CRC and to identify possible
early biomarkers for clinical prognosis.
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