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Abstract #0522

Metabolic signatures of colorectal cancer in biofluids: NMR-based metabolomics of fecal extracts

Yan Lin 1 , Changchun Ma 2 , Zhiwei Shen 1 , zhening wang 1 , and Renhua Wu 1

1 Radiology Department, Second Affiliated Hospital, Shantou University Medical College, Shantou City, Guangdong Province, China, 2 Radiation Oncology, Cancer Hospital, Shantou University Medical College, Guangdong Province, China

This present study is a NMR-based metabolomics approaches coupled with orthogonal projection to least squares discriminant analysis (OPLS-DA) to evaluate the ability to characterize the metabolic fingerprint of fecal extracts from patients with colorectal cancer (CRC) on larger patient cohorts. The most significant metabolites for classification include short-chain fatty acids, alanine, isoleucine, leucine, valine, glutamate, glycerol, suggesting changes in the gut microbial community or malabsorption. These results shows the valuable potential of NMR-based metabonomics of fecal extracts to characterize the systemic metabolic disturbances underlying CRC and to identify possible early biomarkers for clinical prognosis.

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