Abstract #0521
In vivo evaluation of ocular physiology and structural integrity of the optic nerve upon whole eye transplantation using gadolinium-enhanced MRI and diffusion tensor imaging
Yolandi van der Merwe 1,2 , Leon C. Ho 1,3 , Yang Li 4 , Maxine R. Miller 4,5 , Chiaki Komatsu 4 , Hongkun Wang 4 , Michael B. Steketee 5 , Seong-Gi Kim 1,6 , Joel S. Schuman 2,5 , Kia M. Washington 4,5 , Kevin C. Chan 1,5 , and the WET Consortium 5
1
Neuroimaging Laboratory, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
2
Department
of Bioengineering, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
3
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
4
Department
of Plastic and Reconstructive Surgery, University of
Pittsburgh, Pennsylvania, United States,
5
Department
of Ophthalmology, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
6
Center
for Neuroscience Imaging Research, Institute for Basic
Science, Sungkyunkwan University, Suwon, Korea
Whole eye transplantation (WET) provides individuals
with irreversible vision loss the opportunity to receive
an intact visual system. A viable ocular environment
that stimulates adequate blood circulation and
reconstructs axonal integrity is essential in the
restoration of visual function. The purpose of this
study is to demonstrate the viability of our WET model
to assess aqueous humor dynamics and tissue permeability
of the transplanted eye using gadolinium (Gd)-enhanced
MRI. In addition, diffusion tensor imaging was employed
to determine the structural integrity of the optic nerve
following WET.
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