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Abstract #0520

Diffusion tensor imaging and magnitization transfer parameters correlate with the white matter pathology in mild traumatic brain injury

Tsang-Wei Tu 1 , Rashida A. Williams 2 , Jacob D. Lescher 2 , L. Christine Turtzo 2 , and Joseph A. Frank 2

1 Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD - Maryland, United States, 2 Radiology and Imaging Sciences, National Institutes of Health, Maryland, United States

Both DTI and MTR have been shown capable of detecting white matter abnormalities. This study investigates the correlations of DTI and MTR parameters to specific neuropathologies in the time course of rodent weight drop TBI. Comparable to the previous reports, our results suggest that AD and FA are sensitive in reflecting axonal integrity, while RD is able to detect myelin content. The MTR at 20 ppm shows strong correlation with the extent of astrogliosis across TBI time course. Our findings suggest that DTI and MTR are sensitive to multiple neuropathologies, and maybe useful in identifying injury status of mild TBI.

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